AUTHOR=Xu Yirong , Zhang Wei , Shen Feng , Yang Xi , Liu Huilan , Dai Shengbin , Sun Xinchen , Huang Junxing , Guo Qing 

TITLE=YTH Domain Proteins: A Family of m6A Readers in Cancer Progression

JOURNAL=Frontiers in Oncology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.629560

DOI=10.3389/fonc.2021.629560

ISSN=2234-943X

ABSTRACT=<p><italic><underline>N</underline></italic><underline><sup>6</sup></underline>-methyladenosine (m<underline><sup>6</sup></underline>A) is the most abundant internal modification in eukaryotic messenger RNAs (mRNAs). m<sup>6</sup>A RNA methylation is involved in all stages of RNA life cycle, from RNA processing, nuclear output, translation regulation to RNA degradation, indicating that m<sup>6</sup>A has various functions affecting RNA metabolism positively or negatively. Reading proteins are vital in regulating the translation and stability of m<sup>6</sup>A mRNAs positively or negatively. Recent studies have enhanced the understanding of the molecular mechanism of the YT521-B homology (YTH) domain family and the modification of m<sup>6</sup>A. This study aimed to review the specific <underline>mechanisms,</underline> functions, and interactions of the YTH domain protein family. It also discussed future research directions, thus providing new ideas for the clinical diagnosis and targeted therapy of cancer.</p>