AUTHOR=Bispo Saloe , Farias Ticiana D. J. , de Araujo-Souza Patricia Savio , Cintra Ricardo , Santos Hellen Geremias dos , Jorge Natasha Andressa Nogueira , Castro Mauro Antônio Alves , Wajnberg Gabriel , Scherer Nicole de Miranda , Genta Maria Luiza Nogueira Dias , Carvalho Jesus Paula , Villa Luisa Lina , Sichero Laura , Passetti Fabio TITLE=Dysregulation of Transcription Factor Networks Unveils Different Pathways in Human Papillomavirus 16-Positive Squamous Cell Carcinoma and Adenocarcinoma of the Uterine Cervix JOURNAL=Frontiers in Oncology VOLUME=11 YEAR=2021 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.626187 DOI=10.3389/fonc.2021.626187 ISSN=2234-943X ABSTRACT=
Squamous cell carcinoma (SCC) and adenocarcinoma (ADC) are the most common histological types of cervical cancer (CC). The worse prognosis of ADC cases highlights the need for better molecular characterization regarding differences between these CC types. RNA-Seq analysis of seven SCC and three ADC human papillomavirus 16-positive samples and the comparison with public data from non-tumoral human papillomavirus-negative cervical tissue samples revealed pathways exclusive to each histological type, such as the epithelial maintenance in SCC and the maturity-onset diabetes of the young (MODY) pathway in ADC. The transcriptional regulatory network analysis of cervical SCC samples unveiled a set of six transcription factor (TF) genes with the potential to positively regulate long non-coding RNA genes