AUTHOR=Xie Xingwei , Jiang Shanshan , Li Xiang 

TITLE=Nuf2 Is a Prognostic-Related Biomarker and Correlated With Immune Infiltrates in Hepatocellular Carcinoma

JOURNAL=Frontiers in Oncology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.621373

DOI=10.3389/fonc.2021.621373

ISSN=2234-943X

ABSTRACT=<p><italic>Nuf2</italic> participates in the regulation of cell apoptosis and proliferation by regulating the binding of centromere and spindle microtubules to achieve the correct separation of chromosomes. Previous reports have suggested that <italic>Nuf2</italic> may play a role in various human cancers. However, the mechanism and function of <italic>Nuf2</italic> in the development of Hepatocellular carcinoma (HCC) remains uncertain. This study investigated the prognostic potential of <italic>Nuf2</italic> and its relation with immune cell infiltration in HCC. <italic>Nuf2</italic> expression in tumor cells was examined using the TIMER and Oncomine databases, and its prognostic potential was assessed <italic>via</italic> the Kaplan-Meier plotter and GEPIA databases. The relationships between <italic>Nuf2</italic> and tumor immune infiltration were analyzed using TIMER. The relationships between <italic>Nuf2</italic> and biomarkers of tumor immune infiltration were analyzed using TIMER and GEPIA. Here we revealed that <italic>Nuf2</italic> expression increased in tumor tissues containing HCC, and this correlated with poor relapse-free survival, disease-specific survival, progression-free survival, and overall survival in patients with HCC regardless of grades, genders, races, drinking behaviors and other clinical factors. Additionally, high expression of <italic>Nuf2</italic> was positively correlated with differential immune cell infiltration and various immune biomarkers. Our work demonstrated that <italic>Nuf2</italic> could be a potential prognostic biomarker and could be related to tumor immune cell infiltration in HCC.</p>