AUTHOR=Feng Yuhua , Liu Yiping , Zhong Meizuo , Wang Leyuan 

TITLE=Complete Blood Count Score Model Predicts Inferior Prognosis in Primary Central Nervous System Lymphoma

JOURNAL=Frontiers in Oncology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.618694

DOI=10.3389/fonc.2021.618694

ISSN=2234-943X

ABSTRACT=<sec><title>Background</title><p>Primary central nervous system lymphoma (PCNSL), an aggressive type of non-Hodgkin lymphoma, has a poor prognosis. Currently available prognostic scoring systems are inadequate. We therefore aimed to investigate the predictive values of complete blood counts (CBCs) in PCNSL.</p></sec><sec><title>Materials and Methods</title><p>The cohort of this retrospective study comprised 73 PCNSL patients. The predictive values of selected CBCs, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune inflammation index (SII), and systemic inflammation response index (SIRI), were analyzed.</p></sec><sec><title>Results</title><p>Ages and Memorial Sloan Kettering Cancer Center (MSKCC) scores of PCNSL patients correlated with NLR, PLR, and SII values (<italic>p &lt;</italic>0.05). Both age and MSKCC scores correlated with inferior progression-free survival (PFS) and overall survival (OS) (<italic>p &lt;</italic>0.05). High NLR, PLR, SII, and SIRI were significant predictors of shorter PFS and OS (<italic>p &lt;</italic>0.05). NLR, PLR, SII, and SIRI were integrated to generate a “CBC score” model that accurately stratified PCNSL patients into three risk groups. The median PFS for low-risk, intermediate-risk, and high-risk groups were 24 ((12.458–35.542), 17 (10.626–23.374), and 9 (8.893–19.107) months, respectively (<italic>p</italic> = 0.011), and the median OS were 33 (19.175–46.825), 18 (16.368–19.632), and 9 (6.521–11.479) months, respectively (<italic>p</italic> = 0.008). Multivariate Cox regression model showed that MSKCC score (hazard ratio (HR) = 3.791, <italic>p</italic> &lt;0.001), PLR (HR = 1.003, <italic>p</italic> = 0.013), and CBC score (HR = 1.873, <italic>p</italic> = 0.011) were independent predictors for PFS, whereas MSKCC score (HR = 4.128, <italic>p</italic> &lt;0.001), PLR (HR = 1.003, <italic>p</italic> = 0.005), and CBC score (HR = 1.907, <italic>p</italic> = 0.004) were independent predictors for OS.</p></sec><sec><title>Conclusion</title><p>The CBC score model may be a promising predictive system for PCNSL patients.</p></sec>