AUTHOR=Wang Jing , Sha Yongqiang , Sun Tao 

TITLE=m6A Modifications Play Crucial Roles in Glial Cell Development and Brain Tumorigenesis

JOURNAL=Frontiers in Oncology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.611660

DOI=10.3389/fonc.2021.611660

ISSN=2234-943X

ABSTRACT=<p>RNA methylation is a reversible post-transcriptional modification to RNA and has a significant impact on numerous biological processes. <italic>N</italic><sup>6</sup>-methyladenosine (m<sup>6</sup>A) is known as one of the most common types of eukaryotic mRNA methylation modifications, and exists in a wide variety of organisms, including viruses, yeast, plants, mice, and humans. Widespread and dynamic m<sup>6</sup>A methylation is identified in distinct developmental stages in the brain, and controls development of neural stem cells and their differentiation into neurons, glial cells such as oligodendrocytes and astrocytes. Here we summarize recent advances in our understanding of RNA methylation regulation in brain development, neurogenesis, gliogenesis, and its dysregulation in brain tumors. This review will highlight biological roles of RNA methylation in development and function of neurons and glial cells, and provide insights into brain tumor formation, and diagnostic and treatment strategies.</p>