AUTHOR=Wang Jiaqiang , Cheng Chien-shan , Lu Yan , Sun Shen , Huang Shaoqiang 

TITLE=Volatile Anesthetics Regulate Anti-Cancer Relevant Signaling

JOURNAL=Frontiers in Oncology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.610514

DOI=10.3389/fonc.2021.610514

ISSN=2234-943X

ABSTRACT=<p>Volatile anesthetics are widely used inhalation anesthetics in clinical anesthesia. In recent years, the regulation of anti-cancer relevant signaling of volatile anesthetics has drawn the attention of investigators. However, their underlying mechanism remains unclear. This review summarizes the research progress on the regulation of anti-cancer relevant signaling of volatile anesthetics, including sevoflurane, desflurane, xenon, isoflurane, and halothane <italic>in vitro</italic>, <italic>in vivo</italic>, and clinical studies. The present review article aims to provide a general overview of regulation of anti-cancer relevant signaling and explore potential underlying molecular mechanisms of volatile anesthetics. It may promote promising insights of guiding clinical anesthesia procedure and instructing enhance recovery after surgery (ERAS) with latent benefits.</p>