AUTHOR=Cordova-Delgado Miguel , Pizarro Gonzalo , Pinto Mauricio P. , Herrera Maria Elisa , Garrido Marcelo 

TITLE=Case Report: Molecular Features and Treatment Options for Small Bowel Adenocarcinoma

JOURNAL=Frontiers in Oncology

VOLUME=11

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.593561

DOI=10.3389/fonc.2021.593561

ISSN=2234-943X

ABSTRACT=<p>Small bowel adenocarcinoma (SBA) is a rare malignancy characterized by poor prognosis. Recent efforts have sought to elucidate the genetic landscape and the molecular drivers behind this disease. Herein, we report the main molecular alterations in two metastatic (stage IV) SBA patients. Interestingly, one of them had gene alterations that affected signaling pathways previously described for SBA. However, a second patient displayed previously unreported alterations in this particular tumor type. Based on these findings we discuss potential treatment options for patients affected by this rare, aggressive disease.</p>