AUTHOR=Yang Jun , Wen Zhengqi , Li Wenliang , Sun Xianghua , Ma Junrui , She Xueke , Zhang Hongbin , Tu Changling , Wang Guoqiang , Huang Depei , Shen Xudong , Dong Jian , Zhang Hushan TITLE=Immune Microenvironment: New Insight for Familial Adenomatous Polyposis JOURNAL=Frontiers in Oncology VOLUME=11 YEAR=2021 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.570241 DOI=10.3389/fonc.2021.570241 ISSN=2234-943X ABSTRACT=

Currently, the main treatment for familial adenomatous polyposis (FAP) is surgery, however, surgery is far from ideal as there are many complications such as uncontrollable bowel movements, pouch inflammation, anastomotic stricture, and secondary fibroids. Therefore, it is necessary to further expand the understanding of FAP and develop new treatments for FAP. The immune microenvironment including immune cells and cytokines, plays an important role in FAP and the progression of FAP to adenocarcinoma, thus it may be a promising treatment for FAP. In the current review, we summarized the recent progress in the immune microenvironment of FAP.