AUTHOR=Jiang Shaotao , Fu Rongdang , Shi Jiewei , Wu Huijie , Mai Jialuo , Hua Xuefeng , Chen Huan , Liu Jie , Lu Minqiang , Li Ning TITLE=CircRNA-Mediated Regulation of Angiogenesis: A New Chapter in Cancer Biology JOURNAL=Frontiers in Oncology VOLUME=11 YEAR=2021 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.553706 DOI=10.3389/fonc.2021.553706 ISSN=2234-943X ABSTRACT=

Angiogenesis is necessary for carcinoma progression and is regulated by a variety of pro- and anti-angiogenesis factors. CircRNAs are RNA molecules that do not have a 5’-cap or a 3’-polyA tail and are involved in a variety of biological functions. While circRNA-mediated regulation of tumor angiogenesis has received much attention, the detailed biological regulatory mechanism remains unclear. In this review, we investigated circRNAs in tumor angiogenesis from multiple perspectives, including its upstream and downstream factors. We believe that circRNAs have natural advantages and great potential for the diagnosis and treatment of tumors, which deserves further exploration.