AUTHOR=Lou Jianyao , Zhou Yunxiang , Feng Zengyu , Ma Mindi , Yao Yihan , Wang Yali , Deng Yongchuan , Wu Yulian 

TITLE=Caspase-Independent Regulated Necrosis Pathways as Potential Targets in Cancer Management

JOURNAL=Frontiers in Oncology

VOLUME=10

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.616952

DOI=10.3389/fonc.2020.616952

ISSN=2234-943X

ABSTRACT=<p>Regulated necrosis is an emerging type of cell death independent of caspase. Recently, with increasing findings of regulated necrosis in the field of biochemistry and genetics, the underlying molecular mechanisms and signaling pathways of regulated necrosis are gradually understood. Nowadays, there are several modes of regulated necrosis that are tightly related to cancer initiation and development, including necroptosis, ferroptosis, parthanatos, pyroptosis, and so on. What’s more, accumulating evidence shows that various compounds can exhibit the anti-cancer effect <italic>via</italic> inducing regulated necrosis in cancer cells, which indicates that caspase-independent regulated necrosis pathways are potential targets in cancer management. In this review, we expand the molecular mechanisms as well as signaling pathways of multiple modes of regulated necrosis. We also elaborate on the roles they play in tumorigenesis and discuss how each of the regulated necrosis pathways could be therapeutically targeted.</p>