AUTHOR=Slagter Astrid E. , Vollebergh Marieke A. , Jansen Edwin P. M. , van Sandick Johanna W. , Cats Annemieke , van Grieken Nicole C. T. , Verheij Marcel 

TITLE=Towards Personalization in the Curative Treatment of Gastric Cancer

JOURNAL=Frontiers in Oncology

VOLUME=10

YEAR=2020

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.614907

DOI=10.3389/fonc.2020.614907

ISSN=2234-943X

ABSTRACT=<p>Gastric cancer is the fifth most common cancer worldwide and has a high mortality rate. In the last decades, treatment strategy has shifted from an exclusive surgical approach to a multidisciplinary strategy. Treatment options for patients with resectable gastric cancer as recommended by different worldwide guidelines, include perioperative chemotherapy, pre- or postoperative chemoradiotherapy and postoperative chemotherapy. Although gastric cancer is a heterogeneous disease with respect to patient-, tumor-, and molecular characteristics, the current standard of care is still according to a one-size-fits-all approach. In this review, we discuss the background of the different treatment strategies in resectable gastric cancer including the current standard, the specific role of radiotherapy, and describe the current areas of research and potential strategies for personalization of therapy.</p>