AUTHOR=Xia Chuanyou , Olsen Thale Kristin , Zirakzadeh A. Ali , Almamoun Radwa , Sjöholm Louise K. , Dahlström Jenny , Sjöberg Jan , Claesson Hans-Erik , Johnsen John Inge  , Winqvist Ola , Xu Dawei , Ekström Tomas J. , Björkholm Magnus , Strååt Klas 

TITLE=Hodgkin Lymphoma Monozygotic Triplets Reveal Divergences in DNA Methylation Signatures

JOURNAL=Frontiers in Oncology

VOLUME=10

YEAR=2020

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.598872

DOI=10.3389/fonc.2020.598872

ISSN=2234-943X

ABSTRACT=<p>We studied DNA methylation profiles in four different cell populations from a unique constellation of monozygotic triplets in whom two had developed Hodgkin Lymphoma (HL). We detected shared differences in DNA methylation signatures when comparing the two HL-affected triplets with the non-affected triplet. The differences were observed in naïve B-cells and marginal zone-like B-cells. DNA methylation differences were also detected when comparing each of the HL-affected triplets against each other. Even though we cannot determine whether treatment and/or disease triggered the observed differences, we believe our data are important on behalf of forthcoming studies, and that it might provide important clues for a better understanding of HL pathogenesis.</p>