AUTHOR=Tang Ying , Jiang Mei , Jiang Hai-Mei , Ye Zeng Jie , Huang Yu-Sheng , Li Xiu-Shen , Qin Bin-Yu , Zhou Rui-Sheng , Pan Hua-Feng , Zheng Da-Yong 

TITLE=The Roles of circRNAs in Liver Cancer Immunity

JOURNAL=Frontiers in Oncology

VOLUME=10

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.598464

DOI=10.3389/fonc.2020.598464

ISSN=2234-943X

ABSTRACT=<p>Circular RNAs (circRNAs) are stable covalently closed non-coding RNAs (ncRNAs). Many studies indicate that circRNAs are involved in the pathological and physiological processes of liver cancer. However, the functions of circRNAs in liver cancer immunity are less known. In this review, we summarized the functions of circRNAs in liver cancer, including proliferative, metastasis and apoptosis, liver cancer stemness, cell cycle, immune evasion, glycolysis, angiogenesis, drug resistance/sensitizer, and senescence. Immune escape is considered to be one of the hallmarks of cancer development, and circRNA participates in the immune escape of liver cancer cells by regulating natural killer (NK) cell function. CircRNAs may provide new ideas for immunotherapy in liver cancer.</p>