AUTHOR=Shi Mingyu , Zhang Hongzhi , Yao Guozhong , Wu Jianjun , Zhu Chuming , Zhang Xu , Ren Yuan TITLE=The Role of Tumor Deposits in Predicting the Efficacy of Chemotherapy in Stage III Colon Cancer JOURNAL=Frontiers in Oncology VOLUME=10 YEAR=2020 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.586603 DOI=10.3389/fonc.2020.586603 ISSN=2234-943X ABSTRACT=Purpose

To evaluate the role of tumor deposits (TDs) in predicting the efficacy of chemotherapy in stage III colon cancer.

Methods

Using the SEER∗Stat software Version 8.3.6, we started with a national cohort of colon cancer cases diagnosed between 2004 and 2016. We used the χ2 (Chi-square) test to compare differences between different categorical variables according to the number of TDs. The Cox proportional hazards regression model was used to determine the independent association of different clinical and pathological variables with CSS, which were adjusted for other significant prognostic factors.

Results

We have identified 29,017 patients diagnosed with stage III colon cancer from the SEER database. The results of multivariate analyses showed that patients with the receipt of chemotherapy had 54.7% decreased risk of cancer-specific mortality compared with those not (HR = 0.453, 95% CI = 0.425–0.483, P < 0.0001) in the no-TD group; In the 1–2-TD group, patients with the receipt of chemotherapy had 56.8% decreased risk of cancer-specific mortality compared with those not (HR = 0.432, 95% CI = 0.364–0.512, P < 0.0001); In the ≥3-TD group, patients with the receipt of chemotherapy had 51.8% decreased risk of cancer-specific mortality compared with those not (HR = 0.482, 95% CI = 0.389–0.597, P < 0.0001).

Conclusions

Our study demonstrated that the presence of TDs was associated with a dismal prognosis and high number of TDs would also contribute to the worse survival of colon cancer. High number of TDs did not affect the survival benefit of chemotherapy in stage III colon cancer.