AUTHOR=Wu Donglu , Jin Jingji , Qiu Zhidong , Liu Da , Luo Haoming 

TITLE=Functional Analysis of O-GlcNAcylation in Cancer Metastasis

JOURNAL=Frontiers in Oncology

VOLUME=10

YEAR=2020

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.585288

DOI=10.3389/fonc.2020.585288

ISSN=2234-943X

ABSTRACT=<p>One common and reversible type of post-translational modification (PTM) is the addition of <italic>O</italic>-linked β-N-acetylglucosamine (<italic>O</italic>-GlcNAc) modification (<italic>O</italic>-GlcNAcylation), and its dynamic balance is controlled by <italic>O</italic>-GlcNAc transferase (OGT) and glycoside hydrolase <italic>O</italic>-GlcNAcase (OGA) through the addition or removal of <italic>O</italic>-GlcNAc groups. A large amount of research data confirms that proteins regulated by <italic>O</italic>-GlcNAcylation play a pivotal role in cells. In particularly, imbalanced levels of OGT and <italic>O</italic>-GlcNAcylation have been found in various types of cancers. Recently, increasing evidence shows that imbalanced <italic>O</italic>-GlcNAcylation directly or indirectly impacts the process of cancer metastasis. This review summarizes the current understanding of the influence of <italic>O</italic>-GlcNAc-proteins on the regulation of cancer metastasis. It will provide a theoretical basis to further elucidate of the molecular mechanisms underlying cancer emergence and progression.</p>