AUTHOR=Zinter Matt S. , Dvorak Christopher C. , Auletta Jeffery J. 

TITLE=How We Treat Fever and Hypotension in Pediatric Hematopoietic Cell Transplant Patients

JOURNAL=Frontiers in Oncology

VOLUME=10

YEAR=2020

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.581447

DOI=10.3389/fonc.2020.581447

ISSN=2234-943X

ABSTRACT=<p>Pediatric allogeneic hematopoietic cell transplant (HCT) survival is limited by the development of post-transplant infections. In this overview, we discuss a clinical approach to the prompt recognition and treatment of fever and hypotension in pediatric HCT patients. Special attention is paid to individualized hemodynamic resuscitation, thorough diagnostic testing, novel anti-pathogen therapies, and the multimodal support required for recovery. We present three case vignettes that illustrate the complexities of post-HCT sepsis and highlight best practices that contribute to optimal transplant survival in children.</p>