AUTHOR=Oronsky Bryan , Reid Tony R. , Oronsky Arnold , Sandhu Navjot , Knox Susan J. 

TITLE=A Review of Newly Diagnosed Glioblastoma

JOURNAL=Frontiers in Oncology

VOLUME=10

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.574012

DOI=10.3389/fonc.2020.574012

ISSN=2234-943X

ABSTRACT=<p>Glioblastoma is an aggressive and inevitably recurrent primary intra-axial brain tumor with a dismal prognosis. The current mainstay of treatment involves maximally safe surgical resection followed by radiotherapy over a 6-week period with concomitant temozolomide chemotherapy followed by temozolomide maintenance. This review provides a summary of the epidemiological, clinical, histologic and genetic characteristics of newly diagnosed disease as well as the current standard of care and potential future therapeutic prospects.</p>