AUTHOR=Azizi Alexander A. , Hadjinicolaou Andreas V. , Goncalves Carla , Duckworth Adam , Basu Bristi 

TITLE=Update on the Genetics of and Systemic Therapy Options for Combined Hepatocellular Cholangiocarcinoma

JOURNAL=Frontiers in Oncology

VOLUME=10

YEAR=2020

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.570958

DOI=10.3389/fonc.2020.570958

ISSN=2234-943X

ABSTRACT=<p>Combined hepatocellular-cholangiocarcinoma (cHCC-ICC) is an uncommon and aggressive form of primary liver cancer. Currently, there are no international guidelines for optimal management. For localized tumors, radical resection represents the preferred treatment option, whereas for advanced tumors, systemic therapies recommended for intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) are often selected. Emerging information from comparative cohort studies, genomic and transcriptomic data sets are starting to build a case for rationalized approaches to systemic treatment in the advanced setting specific to cHCC-ICC.</p>