AUTHOR=Zhu Ji , Chen Xinyuan , Yang Bining , Bi Nan , Zhang Tao , Men Kuo , Dai Jianrong 

TITLE=Evaluation of Automatic Segmentation Model With Dosimetric Metrics for Radiotherapy of Esophageal Cancer

JOURNAL=Frontiers in Oncology

VOLUME=10

YEAR=2020

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.564737

DOI=10.3389/fonc.2020.564737

ISSN=2234-943X

ABSTRACT=<p><bold>Background and Purpose:</bold> Automatic segmentation model is proven to be efficient in delineation of organs at risk (OARs) in radiotherapy; its performance is usually evaluated with geometric differences between automatic and manual delineations. However, dosimetric differences attract more interests than geometric differences in the clinic. Therefore, this study aimed to evaluate the performance of automatic segmentation with dosimetric metrics for volumetric modulated arc therapy of esophageal cancer patients.</p><p><bold>Methods:</bold> Nineteen esophageal cancer cases were included in this study. Clinicians manually delineated the target volumes and the OARs for each case. Another set of OARs was automatically generated using convolutional neural network models. The radiotherapy plans were optimized with the manually delineated targets and the automatically delineated OARs separately. Segmentation accuracy was evaluated by Dice similarity coefficient (DSC) and mean distance to agreement (MDA). Dosimetric metrics of manually and automatically delineated OARs were obtained and compared. The clinically acceptable dose difference and volume difference of OARs between manual and automatic delineations are supposed to be within 1 Gy and 1%, respectively.</p><p><bold>Results:</bold> Average DSC values were greater than 0.92 except for the spinal cord (0.82), and average MDA values were &lt;0.90 mm except for the heart (1.74 mm). Eleven of the 20 dosimetric metrics of the OARs were not significant (<italic>P</italic> &gt; 0.05). Although there were significant differences (<italic>P</italic> &lt; 0.05) for the spinal cord (D2%), left lung (V10, V20, V30, and mean dose), and bilateral lung (V10, V20, V30, and mean dose), their absolute differences were small and acceptable for the clinic. The maximum dosimetric metrics differences of OARs between manual and automatic delineations were ΔD2% = 0.35 Gy for the spinal cord and ΔV30 = 0.4% for the bilateral lung, which were within the clinical criteria in this study.</p><p><bold>Conclusion:</bold> Dosimetric metrics were proposed to evaluate the automatic delineation in radiotherapy planning of esophageal cancer. Consequently, the automatic delineation could substitute the manual delineation for esophageal cancer radiotherapy planning based on the dosimetric evaluation in this study.</p>