AUTHOR=Lee Hyunji , Kim Minhee , Kim Seon-Hwan , Tran Quangdon , Kong Gyeyeong , Kim Chaeyeong , Kwon So Hee , Park Jisoo , Park Jin Bong , Park Sungjin , Park Jongsun 

TITLE=Alpha-Methylacyl-CoA Racemase (AMACR), a Potential New Biomarker for Glioblastoma

JOURNAL=Frontiers in Oncology

VOLUME=10

YEAR=2020

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.550673

DOI=10.3389/fonc.2020.550673

ISSN=2234-943X

ABSTRACT=<p>Alpha-Methylacyl-CoA racemase (AMACR), which was initially discovered as a prostate cancer marker, is critical for the chiral inversion mechanism of branched-chain fatty acids. However, the function of AMACR in brain tumors has not been investigated. In this study, AMACR appeared to be involved in glioblastoma. The protein and mRNA levels of AMACR were highly elevated in glioblastoma. Downregulation of AMACR inhibited cell proliferation. Comprehensive analysis of the public REMBRANDT GBM dataset also confirmed that the level of AMACR expression was correlated with the clinical prognosis of glioma patients. In summary, these findings indicate that AMACR expression is increased in a glioblastoma cell line and glioma patients, suggesting that AMACR might be a potential diagnostic marker and therapeutic target for cancer, including glioma.</p>