AUTHOR=Li Ziying , Yin Yanxue , Jin Weiwei , Zhang Bo , Yan Han , Mei Heng , Wang Huafang , Guo Tao , Shi Wei , Hu Yu 

TITLE=Tissue Factor-Targeted “O2-Evolving” Nanoparticles for Photodynamic Therapy in Malignant Lymphoma

JOURNAL=Frontiers in Oncology

VOLUME=10

YEAR=2020

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.524712

DOI=10.3389/fonc.2020.524712

ISSN=2234-943X

ABSTRACT=<p>Vascular-targeted PDT (vPDT) has produced promising results in the treatment of many cancers, including drug-resistant ones, but little is known about its efficacy in lymphoma. Unfortunately, the lack of a specific therapeutic target and a hypoxic microenvironment for lymphoma jeopardizes the efficacy of vPDT severely. In this study, we designed a lymphoma tissue factor-targeted “O<sub>2</sub>-evolving” strategy combining PDT with catalase and HMME-encapsulated, EGFP-EGF1-modified PEG-PLGA nanoparticles (CENPs) to boost PDT efficiency; this combination takes advantage of the low oxygen tension of lymphoma. In our results, CENPs accumulated effectively in the vascular lymphoma <italic>in vivo</italic> and <italic>in vitro</italic>, and this accumulation increased further with PDT treatment. Per positron emission tomography imaging, combining CENPs with PDT inhibited lymphoma glucose metabolism significantly. The expression of hypoxia-inducible factor (HIF)-1α in the entrapped catalase groups reduced markedly. These data show that the combined administration of PDT and CENPs can prompt tissue factor-cascade-targeted and self-supply of oxygen and that it has a good therapeutic effect on malignant lymphoma.</p>