AUTHOR=Korakiti Anna-Maria , Moutafi Myrto , Zografos Eleni , Dimopoulos Meletios-Athanasios , Zagouri Flora 

TITLE=The Genomic Profile of Pregnancy-Associated Breast Cancer: A Systematic Review

JOURNAL=Frontiers in Oncology

VOLUME=10

YEAR=2020

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.01773

DOI=10.3389/fonc.2020.01773

ISSN=2234-943X

ABSTRACT=<p>Breast cancer is the most common malignancy diagnosed during pregnancy. Strong data on the genomic profile of pregnancy-associated breast cancer are lacking. This systematic review aims to integrate and analyze all existing data from the literature regarding the genomic background and the gene mutational patterns of pregnancy-associated breast cancer. Using various genomic analysis methods, multiple differentially expressed genes and numerous non-silent mutations have been detected. More particularly, our review demonstrates the aberrant expression of several oncogenes (e.g., <italic>MYC, SRC, FOS</italic>), tumor suppressor genes (e.g., <italic>TP53, PTEN, CAV1</italic>), apoptosis regulators (e.g., <italic>PDCD4, BCL2, BIRC5</italic>), transcription regulators (e.g., <italic>JUN, KLF1, SP110</italic>), genes involved in DNA repair mechanisms (e.g., Sig20, <italic>BRCA1, BRCA2, FEN1</italic>), in cell proliferation (e.g., <italic>AURKA, MKI67</italic>), in the immune response (e.g., <italic>PD1, PDL1</italic>), and in other significant biological processes (e.g., protein modification, internal cell motility). Further research on the genomic profile of pregnancy-associated breast cancer is urgently required in order to identify potential biomarkers facilitating early-stage diagnosis and individualized therapy.</p>