AUTHOR=Salvioni Chiabotti Paolo , Bisig Bettina , Cairoli Anne , Hajdu Steven D. , Lovey Pierre-Yves , Milowich Dina , Ziadi Sonia , Du Pasquier Renaud , Brouland Jean-Philippe , de Leval Laurence 

TITLE=Meningeal Relapse of Nodular Lymphocyte Predominant Hodgkin Lymphoma Transformed to T-Cell/Histiocyte-Rich Large B-Cell Lymphoma: A Case Report

JOURNAL=Frontiers in Oncology

VOLUME=10

YEAR=2020

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.01745

DOI=10.3389/fonc.2020.01745

ISSN=2234-943X

ABSTRACT=<p>Central nervous system involvement in Hodgkin lymphoma is extremely rare, especially in nodular lymphocyte predominant Hodgkin lymphoma (NLPHL), which usually carries a favorable prognosis. Here we report a case of a young patient with NLPHL, who developed a progressive and fatal neurological deterioration requiring a very extensive work-up including two biopsies to obtain the diagnosis of T-cell/histiocyte-rich large B-cell lymphoma like transformation. This report, which includes post-mortem analysis, highlights the correlations between clinical, radiological, and biological data but also the difficulties encountered in reaching the correct diagnosis.</p>