AUTHOR=Chen Xiaoyong , Wang Guojun , Zhang Jianhe , Zhang Gaoqi , Lin Yuanxiang , Lin Zhangya , Gu Jianjun , Kang Dezhi , Ding Chenyu 

TITLE=A Novel Scoring System Based on Preoperative Routine Blood Test in Predicting Prognosis of Atypical Meningioma

JOURNAL=Frontiers in Oncology

VOLUME=10

YEAR=2020

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.01705

DOI=10.3389/fonc.2020.01705

ISSN=2234-943X

ABSTRACT=<sec><title>Purpose</title><p>The aim of this study was to explore the correlation and clinical significance of preoperative fibrinogen and neutrophil-lymphocyte ratio (F-NLR) scoring system with 3-year progression-free survival (PFS) of patients with atypical meningioma.</p></sec><sec><title>Materials and Methods</title><p>Clinical, pathological, radiological, and laboratory variables were collected to analyze their correlation with 3-year PFS in the training set with 163 patients. Patients were classified by different F-NLR scores (0, 1, or 2). External validation for the predictive value of F-NLR scoring system was performed in the validation set with 105 patients.</p></sec><sec><title>Results</title><p>Overall, 37.3% (100 of 268) of the enrolled patients were male. The scoring system showed good performance in predicting 3-year PFS (AUC = 0.872, 95%CI = 0.811–0.919, sensitivity = 66.1%, specificity = 93.3%, and <italic>Youden</italic> index = 0.594). DeLong’s test indicated that the AUC of F-NLR scoring system was significantly greater than that of fibrinogen level and NLR (<italic>Z</italic> = 2.929, <italic>P</italic> = 0.003; <italic>Z</italic> = 3.376, <italic>P</italic> &lt; 0.001). Multivariate Cox analysis revealed that tumor size (HR = 1.39, 95%CI = 1.10–1.76, <italic>P</italic> = 0.007), tumor location (HR = 3.11, 95%CI = 1.60–6.95, <italic>P</italic> = 0.001), and F-NLR score (score of 1: HR = 12.78, 95%CI = 3.78–43.08, <italic>P</italic> &lt; 0.001; score of 2: HR = 44.58, 95%CI = 13.02–152.65, <italic>P</italic> &lt; 0.001) remained significantly associated with 3-year PFS. The good predictive performance of F-NLR scoring system was also demonstrated in the validation set (AUC = 0.824, 95%CI = 0.738–0.891, sensitivity = 62.5%, specificity = 87.9%, and <italic>Youden</italic> index = 0.504).</p></sec><sec><title>Conclusion</title><p>Our study confirmed the correlation and clinical significance of preoperative F-NLR scoring system with 3-year PFS of patients with atypical meningioma. A prospective and large-scale study is required to validate our findings.</p></sec>