AUTHOR=Miran Isabelle , Scherer Dominique , Ostyn Pauline , Mazouni Chafika , Drusch Françoise , Bernard Marine , Louvet Emilie , Adam Julien , Mathieu Marie-Christine , Haffa Mariam , Antignac Jean-Philippe , Le Bizec Bruno , Vielh Philippe , Dessen Philippe , Perdry Hervé , Delaloge Suzette , Feunteun Jean 

TITLE=Adipose Tissue Properties in Tumor-Bearing Breasts

JOURNAL=Frontiers in Oncology

VOLUME=Volume 10 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.01506

DOI=10.3389/fonc.2020.01506

ISSN=2234-943X

ABSTRACT=The tissue stroma plays a major role in tumors’ natural history. Important programs for tumor progression such as epithelial-mesenchymal transition are not activated as cell-autonomous processes but under the conditions of cross talk between tumor and stroma. Adipose tissue is a major component of breast stroma. This study compares breast adipose tissues in women with breast tumors to those in healthy women with the ultimate aim of defining a signature that could be translated into biomarkers for cancer risk. In tumor-bearing breasts, we sampled adipose tissues adjacent to, or distant from the tumor. Parameters studied included: adipocytes size and density, immune cell infiltration, vascularization, secretome and gene expression. Adipose tissues from tumor-bearing breasts, whether adjacent to or distant from the tumor, do not differ from each other by any of these parameters. By contrast, adipose tissues from tumor-bearing breasts have the capacity to secrete twice as much interleukin 8 (IL-8) than those from tumor-free breasts and differentially express a set of 200 genes of which many belong to inflammation and integrin signaling pathways. These observations show that adipose tissues from tumor-bearing breasts display unique constitutive properties. We propose that these properties contribute to the permissiveness of the breast tissue to tumor growth as a non-cell autonomous process.