AUTHOR=Xiong Bei , Liu Tao , Luo Ping , Wei Yongchang , Zhou Yi , Liu Minghui , Zhang Yongxi , Wang Hanlun , Zhang Xiaochun , Wang Xinghuan , Zhou Fuling 

TITLE=Prominent Hypercoagulability Associated With Inflammatory State Among Cancer Patients With SARS-CoV-2 Infection

JOURNAL=Frontiers in Oncology

VOLUME=10

YEAR=2020

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.01345

DOI=10.3389/fonc.2020.01345

ISSN=2234-943X

ABSTRACT=<p>Abnormal coagulation parameters and potential benefits of anticoagulant therapy in general population with novel coronavirus pneumonia (COVID-19) have been reported. However, limited data are available on cancer patients. Coagulation indexes and inflammation parameters in 57 cancer patients with SARS-CoV-2 infection with different severity were retrospectively analyzed. We found that D-dimer levels were increased in 33 patients (57.9%, median: 790 ng/mL). Compared with ordinary type patients, severe and critical ill patients had decreased MPV values (<italic>P</italic> = 0.006), prolonged PT (median: 13.3 vs. 11.5 vs. 11.4 s, <italic>P</italic> &lt; 0.001), significant higher D-dimer levels (median: 2,400 vs. 940 vs. 280 ng/mL, <italic>P</italic> &lt; 0.001), higher PCT levels (median: 0.17 vs. 0.055 vs. 0.045 ng/mL, <italic>P</italic> = 0.002), higher IL-6 (median: 20.6 vs. 2.3 vs. 3.0 pg/mL, <italic>P</italic> = 0.040), and decreased PaO<sub>2</sub> (median: 68 vs. 84 vs. 96 mm Hg, <italic>P</italic> &lt; 0.001). Importantly, three patients, one severe and two critical ill type, with increased D-dimer survived after anticoagulant therapy with continuous heparin infusion. Increased D-dimer levels positively correlated with increased PCT levels (<italic>r</italic> = 0.456, <italic>P</italic> = 0.002) and IL-6 levels (<italic>r</italic> = 0.501, <italic>P</italic> = 0.045). A negative correlation between D-dimer levels and PaO<sub>2</sub> levels (<italic>r</italic> = −0.654, <italic>P</italic> = 0.021) were also existed. Cancer patients with COVID-19 showed prominent hypercoagulability associated with severe inflammation, anticoagulation therapy might be useful to improve the prognosis and should be immediately used after the onset of hypercoagulability.</p>