AUTHOR=Fu Yufei , Zheng Qi , Mao Yingying , Jiang Xiyi , Chen Xin , Liu Pei , Lv Bin , Huang Tuxiong , Yang Jiao , Cheng Yongran , Dai Xiaoyi , Dai Chunyan , Wang Xi , Yin Yifei , Song Tengjiao , Jin Weiyang , Zou Chang , Chen Tianhui , Fu Li , Chen Zhe TITLE=WNT2-Mediated FZD2 Stabilization Regulates Esophageal Cancer Metastasis via STAT3 Signaling JOURNAL=Frontiers in Oncology VOLUME=10 YEAR=2020 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.01168 DOI=10.3389/fonc.2020.01168 ISSN=2234-943X ABSTRACT=
Esophageal cancer micro environment factor WNT2 was critical in cancer metastasis. However, very little is known about WNT2 receptors and their role in the malignant progression of ESCC. The clinical significance and underlying molecular mechanisms of FZD2, one of the receptors of WNT2, was further investigated in ESCC. We found that FZD2 expression was positively correlated with WNT2 levels in clinical ESCC specimens through database analysis. Upregulated FZD2 expression was detected in 69% (69/100) of the primary ESCC cases examined, and increased FZD2 expression was significantly correlated with poor prognosis (