AUTHOR=Na Lei , Bai Yu , Sun Yu , Wang Zhuo , Wang Wei , Yuan Lin , Zhao Chenghai 

TITLE=Identification of 9-Core Immune-Related Genes in Bladder Urothelial Carcinoma Prognosis

JOURNAL=Frontiers in Oncology

VOLUME=10

YEAR=2020

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.01142

DOI=10.3389/fonc.2020.01142

ISSN=2234-943X

ABSTRACT=<p><bold>Background:</bold> Immune microenvironment within tumors affects initiation, progression and clinical outcome of human cancers. Here we explored an immune-related gene signature associated with prognosis of patients with bladder urothelial carcinoma.</p><p><bold>Method:</bold> The Cancer Genome Atlas (TCGA) database was interrogated for expressions of immune-related genes in bladder urothelial carcinomas. Integrated bioinformatics analyses were performed to identify prognostic factors.</p><p><bold>Results:</bold> Twenty-seven immune-related genes were revealed significantly associated with patient's overall survival (OS) by univariate Cox proportional hazards regression analysis. Nine-core immune-related genes including <italic>MMP9, PDGFRA, AHNAK, OLR1, RAC3, IGF1, PGF, OAS1</italic>, and <italic>SH3BP2</italic> were selected to construct a risk score model by multivariate Cox proportional hazards regression analysis. Bioinformatics analyses further validated that risk score could be used as an important independent factor in evaluating prognosis.</p><p><bold>Conclusion:</bold> We established a prognostic immune signature for patients with bladder urothelial carcinoma, which may provide novel targets for prediction and therapy of these patients.</p>