AUTHOR=Groot Koerkamp Maureen L. , Vasmel Jeanine E. , Russell Nicola S. , Shaitelman Simona F. , Anandadas Carmel N. , Currey Adam , Vesprini Danny , Keller Brian M. , De-Colle Chiara , Han Kathy , Braunstein Lior Z. , Mahmood Faisal , Lorenzen Ebbe L. , Philippens Marielle E. P. , Verkooijen Helena M. , Lagendijk Jan J. W. , Houweling Antonetta C. , van den Bongard H. J. G. Desiree , Kirby Anna M. 

TITLE=Optimizing MR-Guided Radiotherapy for Breast Cancer Patients

JOURNAL=Frontiers in Oncology

VOLUME=10

YEAR=2020

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.01107

DOI=10.3389/fonc.2020.01107

ISSN=2234-943X

ABSTRACT=<p>Current research in radiotherapy (RT) for breast cancer is evaluating neoadjuvant as opposed to adjuvant partial breast irradiation (PBI) with the aim of reducing the volume of breast tissue irradiated and therefore the risk of late treatment-related toxicity. The development of magnetic resonance (MR)–guided RT, including dedicated MR-guided RT systems [hybrid machines combining an MR scanner with a linear accelerator (MR-linac) or <sup>60</sup>Co sources], could potentially reduce the irradiated volume even further by improving tumour visibility before and during each RT treatment. In this position paper, we discuss MR guidance in relation to each step of the breast RT planning and treatment pathway, focusing on the application of MR-guided RT to neoadjuvant PBI.</p>