AUTHOR=Chen Dong , Li Xing-liang , Wu Biao , Zheng Xiao-bin , Wang Wen-xian , Chen Hua-fei , Dong Yi-yu , Xu Chun-wei , Fang Mei-yu 

TITLE=A Novel Oncogenic Driver in a Lung Adenocarcinoma Patient Harboring an EGFR-KDD and Response to Afatinib

JOURNAL=Frontiers in Oncology

VOLUME=10

YEAR=2020

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.00867

DOI=10.3389/fonc.2020.00867

ISSN=2234-943X

ABSTRACT=<p><bold>Introduction:</bold> Oncogenic mutations in the epidermal growth factor receptor (<italic>EGFR</italic>) occur frequently in patients with lung cancer. These mutations may serve as critical predictive biomarkers in patients with non-small cell lung cancer (NSCLC). Among them, <italic>EGFR</italic> exon 18–25 kinase domain duplication (<italic>EGFR</italic>-KDD) mutations have been identified as a novel <italic>EGFR</italic> gene subtype in NSCLC.</p><p><bold>Case Presentation:</bold> We reported a rare case of a 59-year-old male diagnosed with adenocarcinoma. A biopsy revealed an <italic>EGFR</italic>-KDD identified by the next generation sequencing (NGS). Effective treatment outcome has been observed after administration with afatinib.</p><p><bold>Conclusion:</bold> This case highlights that comprehensive NGS technique is valuable in detecting novel genetic mutations in tumors.</p>