AUTHOR=Chen Wensheng , Chen Zhipeng , Zhang Miaomiao , Tian Yahui , Liu Lu , Lan Ruirui , Zeng Guandi , Fu Xiaolong , Ru Guoqing , Liu Wanting , Chen Liang , Fan Zhenzhen 

TITLE=GATA6 Exerts Potent Lung Cancer Suppressive Function by Inducing Cell Senescence

JOURNAL=Frontiers in Oncology

VOLUME=10

YEAR=2020

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.00824

DOI=10.3389/fonc.2020.00824

ISSN=2234-943X

ABSTRACT=<p>Lung cancer is the leading cause of cancer-related deaths worldwide. Tumor suppressor genes (TSGs) play a critical role in restricting tumorigenesis and impact the therapeutic effect of various treatments. However, TSGs remain to be systemically determined in lung cancer. Here, we identified GATA6 as a potent lung cancer TSG. GATA6 inhibited lung cancer cell growth <italic>in vitro</italic> and tumorigenesis <italic>in vivo</italic>. Mechanistically, GATA6 upregulated p53 and p21 mRNA while it inhibited AKT activation to stabilize p21 protein, thus inducing lung cancer cell senescence. Furthermore, we showed that ectopic expression of GATA6 led to dramatic slowdown of growth rate of established lung tumor xenograft <italic>in vivo</italic>.</p>