AUTHOR=Gesundheit Benjamin , Ben-David Eliel , Posen Yehudit , Ellis Ronald , Wollmann Guido , Schneider E. Marion , Aigner Karl , Brauns Lars , Nesselhut Thomas , Ackva Ingrid , Weisslein Christine , Thaller Arno TITLE=Effective Treatment of Glioblastoma Multiforme With Oncolytic Virotherapy: A Case-Series JOURNAL=Frontiers in Oncology VOLUME=10 YEAR=2020 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.00702 DOI=10.3389/fonc.2020.00702 ISSN=2234-943X ABSTRACT=

Glioblastoma multiforme (GBM) remains an incurable condition, associated with a median survival time of 15 months with best standard of care and 5-year survival rate of <10%. We report on four GBM patients on combination treatment regimens that included oncolytic virus (OV) immunotherapy, who achieved clinical and radiological responses with long-term survival, thus far, of up to 14 years, and good quality of life. We discuss the radiological findings that provide new insights into this treatment, the scientific rationale of this innovative and promising therapy, and considerations for future research.