AUTHOR=Jiao Yang , Zhou Jialiang , Jin Yecheng , Yang Yingxin , Song Mingxu , Zhang Ling , Zhou Jiayan , Zhang Jiwei 

TITLE=Long Non-coding RNA TDRKH-AS1 Promotes Colorectal Cancer Cell Proliferation and Invasion Through the β-Catenin Activated Wnt Signaling Pathway

JOURNAL=Frontiers in Oncology

VOLUME=10

YEAR=2020

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.00639

DOI=10.3389/fonc.2020.00639

ISSN=2234-943X

ABSTRACT=<p>Colorectal cancer (CRC) is a common cancer worldwide, with a lower 5-years survival rate. Recently, long non-coding RNAs (lncRNAs) have been well-studied as the oncogenes or the tumor suppressors in multiple malignancies, including CRC. However, their biological functions and potential mechanisms in human cancer remain unclear. Here, we evaluated the expression of <italic>TDRKH-AS1</italic> in CRC tissues and identified its potential targets. We found that <italic>TDRKH-AS1</italic> is upregulated in majority of CRC patients, which is also significantly correlated with their malignant characteristics and their dismal prognoses. The high expression of <italic>TDRKH-AS1</italic> can promote cancer cell proliferation substantially and invasion based on <italic>in vitro</italic> experiments. We also recognized that the <italic>TDRKH-AS1</italic> targets the β-catenin in the <italic>Wnt</italic> signaling pathway to exert its carcinogenic activity. <italic>TDRKH-AS1</italic> could serve as a promising prognostic predictor and a potential therapeutic target for further early diagnoses and treatments via a non-invasive method.</p>