AUTHOR=Wang Xiaohua , Kou Hongju , He Huiliao , Lu Mingdong , Zhou Lingling , Wang Liang 

TITLE=Difference in Perfusion Parameters Between Gastric Cancer and Gastric Stromal Tumors: Evaluation With Oral Contrast Plus Contrast-Enhanced Ultrasonography

JOURNAL=Frontiers in Oncology

VOLUME=10

YEAR=2020

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.00532

DOI=10.3389/fonc.2020.00532

ISSN=2234-943X

ABSTRACT=<p><bold>Objective:</bold> To explore the difference of perfusion parameters between gastric cancer (GC) and gastric stromal tumors (GSTs) by using oral contrast plus contrast-enhanced ultrasonography (OC+CEUS).</p><p><bold>Methods:</bold> We retrospectively reviewed 149 patients with histologically confirmed gastric lesions (80 patients with GC and 69 patients with GST). OC+CEUS was performed in all patients in the GC group and the GST group before surgery. The cine loops of OC+CEUS of all cases were analyzed. The perfusion parameters including arrival time (AT), time to peak (TTP), basal intensity (BI), and peak intensity (PI) were obtained via a program designed for autotracking contrast quantification (ACQ). The between-group differences in these parameters were compared.</p><p><bold>Results:</bold> According to time-intensity curve (TIC) analysis, high-risk GST had higher PI than low-risk GST (<italic>P</italic> &lt; 0.05). GC had faster AT and higher PI than normal gastric wall (<italic>P</italic> &lt; 0.05); GST had higher PI than normal gastric wall (<italic>P</italic> &lt; 0.05). Furthermore, the GC group had faster AT and higher PI than the GST group (<italic>P</italic> &lt; 0.05). In contrast, the difference in BI and peak time (TTP) between the groups was not significant (<italic>P</italic> &gt; 0.05).</p><p><bold>Conclusion:</bold> AT and PI differ significantly between the GC group and the GST group. As a new method, OC+CEUS has value for the differential diagnosis of GC and GST.</p>