AUTHOR=Wang Wei , Wang Jinzhi , Qiu Pengfei , Sun Tao , Zhang Yingjie , Shao Qian , Xu Min , Liu Xijun , Li Jianbin 

TITLE=Factors Influencing the Incidental Dose Distribution in Internal Mammary Nodes: A Comparative Study

JOURNAL=Frontiers in Oncology

VOLUME=10

YEAR=2020

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.00456

DOI=10.3389/fonc.2020.00456

ISSN=2234-943X

ABSTRACT=<p><bold>Objective:</bold> To investigate the effect of anatomic and technical parameters on the incidental internal mammary lymph node (IMN) irradiation (IIMNI) dose among postmastectomy patients.</p><p><bold>Methods:</bold> We retrospectively delineated the IMN on planning CT images from 138 patients who had undergone postmastectomy radiotherapy (PMRT). We analyzed the IIMNI dose coverage and its relationship with anatomic and technical parameters.</p><p><bold>Results:</bold> The IIMNI mean dose was 32.85 ± 9.49 Gy, and 10 of 138 patients (7.25%) treated with PMRT received ≥45 Gy. In univariate analysis, the body weight, body mass index, body surface area, thoracic transverse diameter (D<sub>T</sub>), ratio of D<sub>T</sub> to the thoracic anteroposterior diameter (D<sub>AP</sub>)(R<sub>T/AP</sub>), planning target volume of IMN (PTV<sub>IMN</sub>) included in PTV (IMNin) and the ratio of IMNin to PTV<sub>IMN</sub> (R<sub>IMNin</sub>) and PTV posterior border were the parameters affecting IIMNI dose. In multivariate analysis, body weight, R<sub>T/AP</sub>, and R<sub>IMNin</sub> were correlative factors that affected IIMNI dose.</p><p><bold>Conclusions:</bold> For patients who underwent PMRT without IMN irradiation (IMNI), there was a wide variety in IIMNI doses. A minority of patients had adequate IIMNI dose coverage, and the higher IIMNI doses were associated with the less body weights and more R<sub>IMNin</sub>.</p>