AUTHOR=Opinto Giuseppina , Vegliante Maria Carmela , Negri Antonio , Skrypets Tetiana , Loseto Giacomo , Pileri Stefano Aldo , Guarini Attilio , Ciavarella Sabino 

TITLE=The Tumor Microenvironment of DLBCL in the Computational Era

JOURNAL=Frontiers in Oncology

VOLUME=10

YEAR=2020

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.00351

DOI=10.3389/fonc.2020.00351

ISSN=2234-943X

ABSTRACT=<p>Among classical exemplifications of tumor microenvironment (TME) in lymphoma pathogenesis, the “effacement model” resembled by diffuse large B cell lymphoma (DLBCL) implies strong cell autonomous survival and paucity of non-malignant elements. Nonetheless, the magnitude of TME exploration is increasing as novel technologies allow the high-resolution discrimination of cellular and extra-cellular determinants at the functional, more than morphological, level. Results from genomic-scale studies and recent clinical trials revitalized the interest in this field, prompting the use of new tools to dissect DLBCL composition and reveal novel prognostic association. Here we revisited major controversies related to TME in DLBCL, focusing on the use of bioinformatics to mine transcriptomic data and provide new insights to be translated into the clinical setting.</p>