AUTHOR=Wang Yujia , Sun Bensen , Wen Xiang , Hao Dan , Du Dan , He Gu , Jiang Xian 

TITLE=The Roles of lncRNA in Cutaneous Squamous Cell Carcinoma

JOURNAL=Frontiers in Oncology

VOLUME=Volume 10 - 2020

YEAR=2020

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.00158

DOI=10.3389/fonc.2020.00158

ISSN=2234-943X

ABSTRACT=Cutaneous squamous cell carcinoma derived from keratinocytes and was the second most non-melanoma skin cancer. Cutaneous squamous cell carcinoma developed rapidly, which was also the leading cause of death in non-melanoma cancers. Lymph node metastasis occurred in 5% of cSCC patients and some patients may even metastasize to viscera. Patients with regional lymphatic metastasis or distant metastases had a less than 20% 10-year survival rate, indicating the substantial challenge in treating advanced and metastatic cSCC. In this review, we summarized the role of lncRNA in cutaneous squamous cell carcinoma to make a better understanding of mutations in cSCC and lay the foundation for effective target therapy of cSCC.