AUTHOR=Li Hailin , Zhang Rui , Wang Siwen , Fang Mengjie , Zhu Yongbei , Hu Zhenhua , Dong Di , Shi Jingyun , Tian Jie 

TITLE=CT-Based Radiomic Signature as a Prognostic Factor in Stage IV ALK-Positive Non-small-cell Lung Cancer Treated With TKI Crizotinib: A Proof-of-Concept Study

JOURNAL=Frontiers in Oncology

VOLUME=10

YEAR=2020

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.00057

DOI=10.3389/fonc.2020.00057

ISSN=2234-943X

ABSTRACT=<p><bold>Objectives:</bold> To identify a computed tomography (CT)-based radiomic signature for predicting progression-free survival (PFS) in stage IV anaplastic lymphoma kinase (<italic>ALK</italic>)-positive non-small-cell lung cancer (NSCLC) patients treated with tyrosine kinase inhibitor (TKI) crizotinib.</p><p><bold>Materials and Methods:</bold> This retrospective proof-of-concept study included a cohort of 63 stage IV <italic>ALK</italic>-positive NSCLC patients who had received TKI crizotinib therapy for model construction and validation. Another independent cohort including 105 stage IV <italic>EGFR</italic>-positive NSCLC patients was also used for external validation in <italic>EGFR</italic>-TKI treatment. We initially extracted 481 quantitative three-dimensional features derived from manually segmented tumor volumes of interest. Pearson's correlation analysis along with the least absolute shrinkage and selection operator (LASSO) penalized Cox proportional hazards regression was successively performed to select critical radiomic features. A CT-based radiomic signature for PFS prediction was obtained using multivariate Cox regression. The performance evaluation of the radiomic signature was conducted using the concordance index (C-index), time-dependent receiver operating characteristic (ROC) analysis, and Kaplan–Meier survival analysis.</p><p><bold>Results:</bold> A radiomic signature containing three features showed significant prognostic performance for <italic>ALK</italic>-positive NSCLC patients in both the training cohort (C-index, 0.744; time-dependent AUC, 0.895) and the validation cohort (C-index, 0.717; time-dependent AUC, 0.824). The radiomic signature could significantly risk-stratify <italic>ALK</italic>-positive NSCLC patients (hazard ratio, 2.181; <italic>P</italic> &lt; 0.001) and outperformed other prognostic factors. However, no significant association with PFS was captured for the radiomic signature in the <italic>EGFR</italic>-positive NSCLC cohort (log-rank tests, <italic>P</italic> = 0.41).</p><p><bold>Conclusions:</bold> The CT-based radiomic features can capture valuable information regarding the tumor phenotype. The proposed radiomic signature was found to be an effective prognostic factor in stage IV <italic>ALK</italic> mutated nonsynchronous nodules in NSCLC patients treated with a TKI.</p>