AUTHOR=Zhang Ye , Fan Lin-Jun , Zhang Yi , Jiang Jun , Qi Xiao-Wei 

TITLE=Long Non-coding Wilms Tumor 1 Antisense RNA in the Development and Progression of Malignant Tumors

JOURNAL=Frontiers in Oncology

VOLUME=10

YEAR=2020

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2020.00035

DOI=10.3389/fonc.2020.00035

ISSN=2234-943X

ABSTRACT=<p>A growing number of studies have shown that long non-coding RNAs (lncRNAs) play an important role in tumor development and progression and are key molecules affecting tumor progression. The lncRNA Wilms tumor 1 antisense RNA (WT1-AS) is specifically expressed in various malignant tumors. In particular, WT1-AS expression is upregulated in colon cancer and breast cancer but is significantly downregulated in cervical cancer, liver cancer, and kidney cancer. The level of WT1-AS expression is closely related to the size, stage, and patient survival rate of these cancers. In this article, we review the modes of action, expression, function, and mechanisms of WT1-AS in different tumors to provide new targets for tumor diagnosis and treatment.</p>