AUTHOR=Moore Amy , Kane Eleanor , Wang Zhaoming , Panagiotou Orestis A. , Teras Lauren R. , Monnereau Alain , Wong Doo Nicole , Machiela Mitchell J. , Skibola Christine F. , Slager Susan L. , Salles Gilles , Camp Nicola J. , Bracci Paige M. , Nieters Alexandra , Vermeulen Roel C. H. , Vijai Joseph , Smedby Karin E. , Zhang Yawei , Vajdic Claire M. , Cozen Wendy , Spinelli John J. , Hjalgrim Henrik , Giles Graham G. , Link Brian K. , Clavel Jacqueline , Arslan Alan A. , Purdue Mark P. , Tinker Lesley F. , Albanes Demetrius , Ferri Giovanni M. , Habermann Thomas M. , Adami Hans-Olov , Becker Nikolaus , Benavente Yolanda , Bisanzi Simonetta , Boffetta Paolo , Brennan Paul , Brooks-Wilson Angela R. , Canzian Federico , Conde Lucia , Cox David G. , Curtin Karen , Foretova Lenka , Gapstur Susan M. , Ghesquières Hervé , Glenn Martha , Glimelius Bengt , Jackson Rebecca D. , Lan Qing , Liebow Mark , Maynadie Marc , McKay James , Melbye Mads , Miligi Lucia , Milne Roger L. , Molina Thierry J. , Morton Lindsay M. , North Kari E. , Offit Kenneth , Padoan Marina , Patel Alpa V. , Piro Sara , Ravichandran Vignesh , Riboli Elio , de Sanjose Silvia , Severson Richard K. , Southey Melissa C. , Staines Anthony , Stewart Carolyn , Travis Ruth C. , Weiderpass Elisabete , Weinstein Stephanie , Zheng Tongzhang , Chanock Stephen J. , Chatterjee Nilanjan , Rothman Nathaniel , Birmann Brenda M. , Cerhan James R. , Berndt Sonja I. TITLE=Genetically Determined Height and Risk of Non-hodgkin Lymphoma JOURNAL=Frontiers in Oncology VOLUME=9 YEAR=2020 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2019.01539 DOI=10.3389/fonc.2019.01539 ISSN=2234-943X ABSTRACT=

Although the evidence is not consistent, epidemiologic studies have suggested that taller adult height may be associated with an increased risk of some non-Hodgkin lymphoma (NHL) subtypes. Height is largely determined by genetic factors, but how these genetic factors may contribute to NHL risk is unknown. We investigated the relationship between genetic determinants of height and NHL risk using data from eight genome-wide association studies (GWAS) comprising 10,629 NHL cases, including 3,857 diffuse large B-cell lymphoma (DLBCL), 2,847 follicular lymphoma (FL), 3,100 chronic lymphocytic leukemia (CLL), and 825 marginal zone lymphoma (MZL) cases, and 9,505 controls of European ancestry. We evaluated genetically predicted height by constructing polygenic risk scores using 833 height-associated SNPs. We used logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI) for association between genetically determined height and the risk of four NHL subtypes in each GWAS and then used fixed-effect meta-analysis to combine subtype results across studies. We found suggestive evidence between taller genetically determined height and increased CLL risk (OR = 1.08, 95% CI = 1.00–1.17, p = 0.049), which was slightly stronger among women (OR = 1.15, 95% CI: 1.01–1.31, p = 0.036). No significant associations were observed with DLBCL, FL, or MZL. Our findings suggest that there may be some shared genetic factors between CLL and height, but other endogenous or environmental factors may underlie reported epidemiologic height associations with other subtypes.