AUTHOR=Quintero-Fabián Saray , Arreola Rodrigo , Becerril-Villanueva Enrique , Torres-Romero Julio César , Arana-Argáez Victor , Lara-Riegos Julio , Ramírez-Camacho Mario Alberto , Alvarez-Sánchez María Elizbeth TITLE=Role of Matrix Metalloproteinases in Angiogenesis and Cancer JOURNAL=Frontiers in Oncology VOLUME=9 YEAR=2019 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2019.01370 DOI=10.3389/fonc.2019.01370 ISSN=2234-943X ABSTRACT=

During angiogenesis, new vessels emerge from existing endothelial lined vessels to promote the degradation of the vascular basement membrane and remodel the extracellular matrix (ECM), followed by endothelial cell migration, and proliferation and the new generation of matrix components. Matrix metalloproteinases (MMPs) participate in the disruption, tumor neovascularization, and subsequent metastasis while tissue inhibitors of metalloproteinases (TIMPs) downregulate the activity of these MMPs. Then, the angiogenic response can be directly or indirectly mediated by MMPs through the modulation of the balance between pro- and anti-angiogenic factors. This review analyzes recent knowledge on MMPs and their participation in angiogenesis.