AUTHOR=Mejia Saldarriaga Mateo , Steinberg Amir , Severson Eric A. , Binder Adam 

TITLE=A Case of CCDC6-RET Fusion Mutation in Adult Acute Lymphoblastic Leukemia (ALL), a Known Activating Mutation Reported in ALL

JOURNAL=Frontiers in Oncology

VOLUME=9

YEAR=2019

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2019.01303

DOI=10.3389/fonc.2019.01303

ISSN=2234-943X

ABSTRACT=<p>We report the case of a patient with B-Cell Acute Lymphoblastic Leukemia (ALL) who was found to harbor a gene fusion involving the <italic>CCDC6</italic> and <italic>RET</italic> genes. Although the <italic>RET</italic> mutations have been identified before in other malignancies, and it is thought to represent a driver mutation in these neoplasms, it has yet to be described in ALL. The identification of known fusion genes conferring activating tyrosine kinase activity in neoplasms can suggest potential therapeutic role of tyrosine kinase inhibitors (TKI), an approach that has been exploited in several other fusion genes.</p>