AUTHOR=Basile Maria Sofia , Mazzon Emanuela , Fagone Paolo , Longo Antonio , Russo Andrea , Fallico Matteo , Bonfiglio Vincenza , Nicoletti Ferdinando , Avitabile Teresio , Reibaldi Michele 

TITLE=Immunobiology of Uveal Melanoma: State of the Art and Therapeutic Targets

JOURNAL=Frontiers in Oncology

VOLUME=9

YEAR=2019

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2019.01145

DOI=10.3389/fonc.2019.01145

ISSN=2234-943X

ABSTRACT=<p>Uveal Melanoma (UM) represents the most common primary intraocular malignant tumor in adults. Although it originates from melanocytes as cutaneous melanoma, it shows significant clinical and biological differences with the latter, including high resistance to immune therapy. Indeed, UM can evade immune surveillance via multiple mechanisms, such as the expression of inhibitory checkpoints (e.g., <italic>PD-L1, CD47, CD200</italic>) and the production of <italic>IDO-1</italic> and soluble <italic>FasL</italic>, among others. More in-depth understanding of these mechanisms will suggest potential targets for the design of novel and more effective management strategies for UM patients.</p>