AUTHOR=De Matteo Elena , García Lombardi Mercedes , Preciado Maria V. , Chabay Paola 

TITLE=Changes in EBV Association Pattern in Pediatric Classic Hodgkin Lymphoma From a Single Institution in Argentina

JOURNAL=Frontiers in Oncology

VOLUME=9

YEAR=2019

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2019.00881

DOI=10.3389/fonc.2019.00881

ISSN=2234-943X

ABSTRACT=<p>In classic Hodgkin lymphoma (cHL), Epstein Barr virus (EBV) association varies worldwide.</p><p><bold>Aims:</bold> Our aim was to analyze EBV association with pediatric cHL for the last 28 years.</p><p><bold>Methods:</bold> EBV presence was evaluated by EBERs <italic>in situ</italic> hybridization and LMP1 immunohistochemistry.</p><p><bold>Results:</bold> Until 2008, we found in pediatric cHL a similar percentage of EBV presence to those observed in adult cHL from developed populations. Nevertheless, in the last 8 years, an unexpected difference in cHL EBV association was proven, along with a slight bias of EBV association with the nodular sclerosis (NS) subtype. Concerning histological subtype distribution, even though MC still prevailed in the whole series, those cases diagnosed as NS showed a sustained rise from 1989 until today.</p><p><bold>Conclusion:</bold> Variations of EBV association of cHL related to geography, age, ethnicity, and histological type have been largely described when compared with different world regions, but interestingly, this single-center revised series brought to light the dynamic process behind the evolution of this relationship over time.</p>