AUTHOR=Yu Min , Hong Weifeng , Ruan Shiye , Guan Renguo , Tu Lei , Huang Bowen , Hou Baohua , Jian Zhixiang , Ma Liheng , Jin Haosheng TITLE=Genome-Wide Profiling of Prognostic Alternative Splicing Pattern in Pancreatic Cancer JOURNAL=Frontiers in Oncology VOLUME=9 YEAR=2019 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2019.00773 DOI=10.3389/fonc.2019.00773 ISSN=2234-943X ABSTRACT=
Alternative splicing (AS) has a critical role in tumor progression and prognosis. Our study aimed to investigate pancreatic cancer-specific AS events using RNA-seq data, gaining systematic insights into potential prognostic predictors. We downloaded 10,623 genes with 45,313 pancreatic cancer-specific AS events from the Cancer Genome Atlas (TCGA) and SpliceSeq database. Cox univariate analyses of overall survival suggested there was a remarkable association between 6,711 AS events and overall survival in pancreatic cancer patients (