AUTHOR=Cavallari Ilaria , Urso Loredana , Sharova Evgeniya , Pasello Giulia , Ciminale Vincenzo 

TITLE=Liquid Biopsy in Malignant Pleural Mesothelioma: State of the Art, Pitfalls, and Perspectives

JOURNAL=Frontiers in Oncology

VOLUME=Volume 9 - 2019

YEAR=2019

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2019.00740

DOI=10.3389/fonc.2019.00740

ISSN=2234-943X

ABSTRACT=Malignant pleural mesothelioma (MPM) is an aggressive tumor linked to asbestos exposure.  Although the risk factors for MPM are well known, the majority of MPM patients are diagnosed at an advanced stage and have a very poor prognosis. Circulating biomarkers for early diagnosis remain to be identified, and the current standard for MPM diagnosis relies on pleural biopsies. Robust non-invasive tests for the screening of asbestos-exposed subjects are therefore an important unmet clinical need.
This review provides a critical summary of recent liquid biopsy-based studies aimed at discovering novel blood-based circulating biomarkers for the early diagnosis and prognostic stratification of MPM patients.