AUTHOR=Khan Shaheer , Sawas Ahmed 

TITLE=Antibody-Directed Therapies: Toward a Durable and Tolerable Treatment Platform for CTCL

JOURNAL=Frontiers in Oncology

VOLUME=9

YEAR=2019

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2019.00645

DOI=10.3389/fonc.2019.00645

ISSN=2234-943X

ABSTRACT=<p>Cutaneous T-cell lymphomas (CTCL) are a rare group of heterogeneous disorders characterized by cutaneous involvement of monoclonal T-lymphocytes. Although indolent at early stages, CTCL can confer significant morbidity, and mortality when advanced. There is an unmet need for tolerable and durable treatments with antibodies recently gaining promise. Here we review approved systemic therapies and discuss select antibodies in development.</p>