AUTHOR=Tu Jiajie , Cheung Hoi-Hung , Lu Gang , Chan Clement Leung-Kwok , Chen Zijiang , Chan Wai-Yee TITLE=microRNA-126 Is a Tumor Suppressor of Granulosa Cell Tumor Mediated by Its Host Gene EGFL7 JOURNAL=Frontiers in Oncology VOLUME=9 YEAR=2019 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2019.00486 DOI=10.3389/fonc.2019.00486 ISSN=2234-943X ABSTRACT=
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at a post-transcriptional level. We examined the role of miR-126 in granulosa cell tumor (GCT) of the ovaries. In tissues from malignant GCT patients miR-126 expression was repressed. We showed that miR-126 could inhibit proliferation, migration, hormone production and promote apoptosis of cancerous granulosa cells (GCs)