AUTHOR=Wegner Rodney E. , Abel Stephen , Hasan Shaakir , Schumacher Lana Y. , Colonias Athanasios 

TITLE=Stereotactic Body Radiotherapy (SBRT) for Oligometastatic Lung Nodules: A Single Institution Series

JOURNAL=Frontiers in Oncology

VOLUME=9

YEAR=2019

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2019.00334

DOI=10.3389/fonc.2019.00334

ISSN=2234-943X

ABSTRACT=<p><bold>Aim:</bold> Lung metastases from an extra-pulmonary origin occasionally present with a limited metastatic disease burden. In cases where metastatectomy is not feasible, stereotactic body radiation therapy (SBRT) represents a non-invasive, efficacious option. We report the outcomes of patients treated with lung SBRT in cases of limited metastatic disease.</p><p><bold>Methods:</bold> We retrospectively reviewed outcomes in 44 patients with 50 lung nodules from various extra-pulmonary malignancies treated with SBRT. Fifty percent of the patients were male and median age was 64. The median number of nodules was 1 and 90% of patients had oligometastatic disease. Thirty-four percent of patients had extra-thoracic disease.</p><p><bold>Results:</bold> Fifty lung nodules were treated with SBRT in 44 patients. Median dose was 48 Gy in 5 fractions with a median biological effective dose (BED) of 100 Gy<sub>10</sub>. Follow-up imaging was available for review in 96% of nodules. Median follow-up was 17.5 months. One year local control was 82%. BED &gt;72 Gy<sub>10</sub> predicted improved local control (90 vs. 57% at 1 year). One year overall survival following SBRT was 66%. There was no difference in overall survival if patients had extra-thoracic disease.</p><p><bold>Conclusion:</bold> Lung SBRT is a safe, effective tool for treatment of limited lung metastases. Dose selection remains important for local control.</p>