AUTHOR=Kong Xiangyi , Zhai Jie , Yan Chengrui , Song Yan , Wang Jing , Bai Xiaofeng , Brown James A. L. , Fang Yi 

TITLE=Recent Advances in Understanding FOXN3 in Breast Cancer, and Other Malignancies

JOURNAL=Frontiers in Oncology

VOLUME=9

YEAR=2019

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2019.00234

DOI=10.3389/fonc.2019.00234

ISSN=2234-943X

ABSTRACT=<p>FOXN3 (forkhead box N3; CHES1: check point suppressor 1) belongs to the forkhead box (FOX) protein family. FOXN3 displays transcriptional inhibitory activity, and is involved in cell cycle regulation and tumorigenesis. FOXN3 is a tumor suppresser and alterations in FOXN3 are found in of a variety of cancers including melanoma, osteosarcoma, and hepatocellular carcinoma. While the roles of FOXN3 role in some cancers have been explored, its role in breast cancer remains unclear. Here we describe current state of knowledge of FOXN3 functions, and focus on its roles (known and potential) in breast cancer.</p>